Make the streusel: Combine the butter, flour, sugar, pumpkin pie spice, pecans, and packet of streusel topping from the box in a medium bowl. Squeeze the streusel into large clumps. Set aside.
Preheat the oven to 325°F. Grease a 9- x 5-inch loaf pan with vegetable shortening and line with parchment paper. Mix the muffin mix, pumpkin pie spice, and a pinch of salt in a small bowl.
Whisk together the pumpkin and egg in a large bowl. Gradually add the dry ingredients until the batter is smooth.
Pour the batter into the prepared loaf pan. Break the streusel into clumps and sprinkle over the batter. Press the streusel gently into the batter.
Bake for 1 hour and 20 minutes or until a toothpick inserted in the center comes out clean with a few moist crumbs, shielding the bread with aluminum foil during the end of baking if the streusel becomes too browned.
Let the loaf cool in the pan for 5 minutes then remove to a wire rack to cool completely.